Hotels in Santee

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15 hotels in Santee for your stay

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Most Booked
Lowest price
Closest to downtown
Highest Rated
85
Hotels in Santee
Public parking
Gym
Wake-up call
+6
"There is an Asian restaurant across the street. It tastes good. I can enjoy such a comfortable meal in the south. I feel very satisfied. Very close to the lake, just a few minutes drive. The hotel is a standard budget motel!"
Very Good
98 reviews
8.6/10
1 night
From MYR 565
Check Availability
63
Hotels in Santee
Parking
EV charging station
Gym
+3
"Every time I drive back to New York from Florida, I will live here. It is convenient and clean. It also accepts pets. There is no microwave in the room. But there is a front desk downstairs. It is still very recommended."
Very Good
99 reviews
8.8/10
1 night
From MYR 483
Check Availability
58
Hotels in Santee
Private parking
Gym
Wi-Fi in public areas
+8
"The breakfast was okay, but the waiter had a mediocre attitude. The hotel is clean and tidy and comfortable. The location of the hotel is also good, basically every time I come back to Florida from the north, I will stay here for one night. Parking is free."
Amazing
105 reviews
9.7/10
1 night
From MYR 544
Check Availability
53
Hotels in Santee
Public parking
Wake-up call
Wi-Fi in public areas
+3
Whether you are travelling for business or pleasure with family or solo to escape or to visit Baymont Inn and Suites offers every guest a comfortable room and a welcome with a smile. From the moment you step through our lobby doors our friendly staff will work hard to make you feel at home. Crisp sheets sincere smiles and our hometown hospitality means that you have arrived at our Baymont.
Good
100 reviews
7.8/10
1 night
From MYR 304
Check Availability
66
Hotels in Santee
Private parking
Gym
Wake-up call
+4
Located in Santee, Comfort Inn & Suites Santee is in the entertainment district, within a 5-minute drive of Santee Cooper Country Club and Santee National Golf Club. This hotel is 1.2 mi (1.9 km) from Santee Town Hall and 1.4 mi (2.2 km) from Santee State Park. Take advantage of recreation opportunities including a fitness center and a seasonal outdoor pool. Additional features at this hotel include complimentary wireless internet access, a fireplace in the lobby, and a vending machine. A complimentary buffet breakfast is included. Featured amenities include a business center, complimentary newspapers in the lobby, and a 24-hour front desk. Free self parking is available onsite. Stay in one of 61 guestrooms featuring plasma televisions. Your pillowtop bed comes with Frette Italian sheets. Complimentary wireless internet access keeps you connected, and satellite programming is available for your entertainment. Bathrooms have shower/tub combinations and hair dryers.
Very Good
100 reviews
8.0/10
1 night
From MYR 398
Check Availability
87
Hotels in Santee
Golf course
Gym
Public parking
+5
The Holiday Inn Santee hotel is perfect for recreational activities. Just off I-95 in Santee, SC, our hotel's location is less than an hour from both Columbia and Charleston, two unique cities to visit for a day trip. For those looking for a little relaxation, there is plenty to do in Santee. Our hotel's guests can enjoy the numerous golf courses that dot this area. Visitors also tend to gravitate towards Lake Marion for fishing, as this area is famous for its striped bass and huge catfish. The beautiful lake is supplemented by the glorious, blooming flowers and the clouds of colorful, flitting butterflies that you can find at the Edisto Memorial Gardens. Those on business trips also find it very easy to get things done in Santee, SC. The hotel's proximity to a number of golf courses can provide a peaceful backdrop for intense meetings and business lunches. The 24-hour Business Center and free Internet access are provided to help you make the most of your time. After a day out on the lake or on the golf courses, come back and enjoy some comfort food in the hotel's restaurant. Let the heated pool work for you after a long day of meetings or play. "Southern hospitality" isn't just a slogan for us; it's our guarantee for great, friendly service. Make your reservation today to experience our brand of South Carolina charm!
Very Good
100 reviews
8.0/10
1 night
From MYR 479
Check Availability
99+
Hotels in Santee
Public parking
Gym
Wi-Fi in public areas
+6
"The breakfast was good and the food was good. The rooms are large and the service is warm. be quiet. There are many restaurants around to eat, which is very convenient. Huanpeng's brand is not bad, the price is moderate, suitable for rest in the middle of the journey."
Amazing
95 reviews
9.4/10
1 night
From MYR 571
Check Availability
34
Hotels in Santee
Private parking
Wi-Fi in public areas
Golf course
+2
"Ummmm wrong room given at start Breakfast was pieces of pastry cut up...o.o Coffee was beyond burnt Least it had a room to be safe from the elements"
100 reviews
6.8/10
Check Availability
79
Hotels in Santee
Private parking
Wi-Fi in public areas
Golf course
+6
Located in Santee, Quality Inn & Suites is within a 15-minute walk of Santee Cooper Country Club and Santee State Park. This hotel is 1.1 mi (1.7 km) from Santee National Golf Club and 1.4 mi (2.2 km) from Santee Town Hall. Take advantage of recreation opportunities such as a seasonal outdoor pool, or other amenities including complimentary wireless internet access and a fireplace in the lobby. Additional features at this hotel include a banquet hall and a vending machine. Grab a bite to eat at one of the hotel's many dining establishments, which include 7 restaurants and a coffee shop/cafe. Quench your thirst with your favorite drink at the bar/lounge. A complimentary full breakfast is served daily from 6:30 AM to 9:30 AM. Featured amenities include a computer station, a 24-hour front desk, and multilingual staff. Free self parking is available onsite. Make yourself at home in one of the 106 air-conditioned rooms featuring LED televisions. Complimentary wireless internet access keeps you connected, and satellite programming is available for your entertainment. Bathrooms have bathtubs and hair dryers. Conveniences include desks and coffee/tea makers, as well as phones with free local calls.
96 reviews
6.0/10
1 night
From MYR 235
Check Availability
36
Hotels in Santee
Public parking
Gym
Wi-Fi in public areas
+10
Experience the charm and warmth of Southern hospitality at Ramada by Wyndham Santee I-95. Conveniently located just off I-95 and US-1559 miles from Charleston International Airport -CHS our hotel welcomes you with free WiFi and parking as well as a bar room service and outdoor pool. Our non-smoking hotel is minutes from South Carolina State University golf courses for a weekend getaway fishing on Lake Marion or the nature trails in Santee State Park.
43 reviews
6.2/10
1 night
From MYR 271
Check Availability
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Trip.com's insights for hotels in Santee

Plan smarter with Trip.com’s data-backed insights on travel seasons so that you can book your Santee hotel at the right time!

What is the cheapest day of the week for hotels in Santee?

Hotel rates in Santee are typically lowest on Saturday, with average nightly rates around MYR 467. Monday tends to be the most expensive, averaging MYR 595 per night.
(Based on Trip.com data from January 15, 2025 to January 15, 2026.)
Mon
Tue
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Thu
Fri
Sat
Sun

Find your unique stays in Santee

Immerse yourself in the vibrant atmosphere of Santee with our handpicked accommodation options

Top hotels in Santee

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Check out these top-booked hotels from the past 30 days!
No.1
6.6/10
73 review

Super 8 by Wyndham Santee

Hotel near Santee
"Good Location"
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No.2
6.4/10
92 review

Red Roof Inn Santee

Hotel near Santee
"Good Location"
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No.3
6.3/10
16 review

Econo Lodge

Hotel near Santee
"Good Location"
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FAQs About Hotels in Santee

What hotel deals are available in Santee?

Trip.com offers various events and deals to its users all year round. You can check the deals page to view Trip.com deals.

Which hotels in Santee have swimming pools?

Tru by Hilton Santee (from MYR 464), Best Western Plus Santee Inn (from MYR 489) and Fairfield Inn & Suites Santee (from MYR 545) are hotels with swimming pools. Stay at any of these hotels to enjoy a swimming pool!

Which hotels in Santee offer free WiFi?

Whether you are travelling for business or vacation, an internet connection is a must for your trip. Best Western Plus Santee Inn (from MYR 489), Fairfield Inn & Suites Santee (from MYR 545) and Baymont by Wyndham Santee (from MYR 270) are popular hotels with free Wi-Fi.

Is Santee pet-friendly?

Tru by Hilton Santee (from MYR 464) allows pets. Take your pets with you during your stay!

Which hotels in Santee have fitness facilities?

Tru by Hilton Santee (from MYR 464), Best Western Plus Santee Inn (from MYR 489) and Fairfield Inn & Suites Santee (from MYR 545) provide fitness facilities. Satisfy your fitness needs even while traveling!

Which hotels in Santee provide high-quality breakfasts?

Holiday Inn SANTEE by IHG (from MYR 451),Tru by Hilton Santee (from MYR 464) and Best Western Plus Santee Inn (from MYR 489) provide high-quality breakfast. Start your day with delicious breakfast!

What is the average hotel price in Santee?

For hotels in Santee, the average price on weekdays is MYR 473, the average price on weekends (Friday–Saturday) is MYR 554.

What are the most popular hotels in Santee?

Santee has many popular hotels. Whether you're traveling for business or going on a vacation, Tru by Hilton Santee (from MYR 464), Best Western Plus Santee Inn (from MYR 489) and Fairfield Inn & Suites Santee (from MYR 545) are preferred hotels.

Hotel Information for Tourists

Number of Reviews
1,130
Total Properties
15
Weekday Avg. Price
MYR 473
Weekend Avg. Price
MYR 554
Trending hotel
Tru by Hilton Santee