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15 hotels in Santee for your stay
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Our top hotel picks are based on price, location, and guest reviews to help you find the best stay.
"There is an Asian restaurant across the street. It tastes good. I can enjoy such a comfortable meal in the south. I feel very satisfied. Very close to the lake, just a few minutes drive. The hotel is a standard budget motel!"
"Every time I drive back to New York from Florida, I will live here. It is convenient and clean. It also accepts pets. There is no microwave in the room. But there is a front desk downstairs. It is still very recommended."
"The breakfast was okay, but the waiter had a mediocre attitude. The hotel is clean and tidy and comfortable. The location of the hotel is also good, basically every time I come back to Florida from the north, I will stay here for one night. Parking is free."
Whether you are travelling for business or pleasure with family or solo to escape or to visit Baymont Inn and Suites offers every guest a comfortable room and a welcome with a smile. From the moment you step through our lobby doors our friendly staff will work hard to make you feel at home. Crisp sheets sincere smiles and our hometown hospitality means that you have arrived at our Baymont.
Located in Santee, Comfort Inn & Suites Santee is in the entertainment district, within a 5-minute drive of Santee Cooper Country Club and Santee National Golf Club. This hotel is 1.2 mi (1.9 km) from Santee Town Hall and 1.4 mi (2.2 km) from Santee State Park.
Take advantage of recreation opportunities including a fitness center and a seasonal outdoor pool. Additional features at this hotel include complimentary wireless internet access, a fireplace in the lobby, and a vending machine.
A complimentary buffet breakfast is included.
Featured amenities include a business center, complimentary newspapers in the lobby, and a 24-hour front desk. Free self parking is available onsite.
Stay in one of 61 guestrooms featuring plasma televisions. Your pillowtop bed comes with Frette Italian sheets. Complimentary wireless internet access keeps you connected, and satellite programming is available for your entertainment. Bathrooms have shower/tub combinations and hair dryers.
The Holiday Inn Santee hotel is perfect for recreational activities. Just off I-95 in Santee, SC, our hotel's location is less than an hour from both Columbia and Charleston, two unique cities to visit for a day trip. For those looking for a little relaxation, there is plenty to do in Santee. Our hotel's guests can enjoy the numerous golf courses that dot this area. Visitors also tend to gravitate towards Lake Marion for fishing, as this area is famous for its striped bass and huge catfish. The beautiful lake is supplemented by the glorious, blooming flowers and the clouds of colorful, flitting butterflies that you can find at the Edisto Memorial Gardens. Those on business trips also find it very easy to get things done in Santee, SC. The hotel's proximity to a number of golf courses can provide a peaceful backdrop for intense meetings and business lunches. The 24-hour Business Center and free Internet access are provided to help you make the most of your time. After a day out on the lake or on the golf courses, come back and enjoy some comfort food in the hotel's restaurant. Let the heated pool work for you after a long day of meetings or play. "Southern hospitality" isn't just a slogan for us; it's our guarantee for great, friendly service. Make your reservation today to experience our brand of South Carolina charm!
"The breakfast was good and the food was good. The rooms are large and the service is warm. be quiet. There are many restaurants around to eat, which is very convenient. Huanpeng's brand is not bad, the price is moderate, suitable for rest in the middle of the journey."
Located in Santee, Quality Inn & Suites is within a 15-minute walk of Santee Cooper Country Club and Santee State Park. This hotel is 1.1 mi (1.7 km) from Santee National Golf Club and 1.4 mi (2.2 km) from Santee Town Hall.
Take advantage of recreation opportunities such as a seasonal outdoor pool, or other amenities including complimentary wireless internet access and a fireplace in the lobby. Additional features at this hotel include a banquet hall and a vending machine.
Grab a bite to eat at one of the hotel's many dining establishments, which include 7 restaurants and a coffee shop/cafe. Quench your thirst with your favorite drink at the bar/lounge. A complimentary full breakfast is served daily from 6:30 AM to 9:30 AM.
Featured amenities include a computer station, a 24-hour front desk, and multilingual staff. Free self parking is available onsite.
Make yourself at home in one of the 106 air-conditioned rooms featuring LED televisions. Complimentary wireless internet access keeps you connected, and satellite programming is available for your entertainment. Bathrooms have bathtubs and hair dryers. Conveniences include desks and coffee/tea makers, as well as phones with free local calls.
Experience the charm and warmth of Southern hospitality at Ramada by Wyndham Santee I-95. Conveniently located just off I-95 and US-1559 miles from Charleston International Airport -CHS our hotel welcomes you with free WiFi and parking as well as a bar room service and outdoor pool. Our non-smoking hotel is minutes from South Carolina State University golf courses for a weekend getaway fishing on Lake Marion or the nature trails in Santee State Park.
43 reviews
6.2/10
1 night
From MYR 271
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Trip.com's insights for hotels in Santee
Plan smarter with Trip.com’s data-backed insights on travel seasons so that you can book your Santee hotel at the right time!
What is the cheapest day of the week for hotels in Santee?
Hotel rates in Santee are typically lowest on Saturday, with average nightly rates around MYR 467. Monday tends to be the most expensive, averaging MYR 595 per night.
(Based on Trip.com data from January 15, 2025 to January 15, 2026.)
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MYR 200
MYR 400
MYR 600
MYR 595
Mon
MYR 566
Tue
MYR 513
Wed
MYR 545
Thu
MYR 590
Fri
MYR 467
Sat
MYR 572
Sun
Find your unique stays in Santee
Immerse yourself in the vibrant atmosphere of Santee with our handpicked accommodation options