Wi-Fi in public areas24-hour front deskParking availableFree parkingPoolEV charging stationGymElevatorPets welcomeLuggage storageWake-up callSmoking areaConference room
6 hotels in Seneca for your stay
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Our top hotel picks are based on price, location, and guest reviews to help you find the best stay.
"Room was clean and the bed linens smelled fresh. The front office staff and maids were all amiable and happy to be helpful. Breakfast was carb city. Did have self made hot waffles, muffins, cereals, yogurt bananas and coffee n juice. We stayed three nights and would be happy to go back."
Welcome to the Hampton Inn & Suites Seneca-Clemson Area, a warm and welcoming hotel just a short distance from Lake Keowee and downtown Seneca, SC. Enjoy easy access to local restaurants, state parks, lakes and leisure amenities including golf. Popular Seneca attractions including the Blue Ridge Mountains, the World of Energy and Clemson University are all close to our relaxed hotel in Seneca, SC. Settle in to a beautifully decorated guest room or suite, where you can stay connected with free WiFi at the ergonomic desk, watch the satellite TV and get a great night's sleep on the clean and fresh Hampton bed. Other great amenities include an in-room microwave and refrigerator and guest laundry facilities are available at this Seneca hotel.
Every morning, enjoy Hampton's free hot breakfast buffet, offering everything from light continental favorites to hot items and buy snacks at any time from the 24-hour Suite Shop. Enjoy free tea and coffee in the modern lobby, 24-hours a day and ask our friendly staff for advice on what to see and do during your stay. Stay connected with the free business center or hold a meeting in the 600 sq.ft. conference room. Energize in the free fitness center, swim in the outdoor, saltwater pool or relax under an umbrella on the poolside patio area.
Friendly service, clean rooms, comfortable surroundings, every time. If you're not satisfied, we don't expect you to pay. That's our commitment and your guarantee. That's 100% Hampton.
Welcome to your spacious golf course retreat in Seneca, South Carolina, just 15 minutes from Clemson University and minutes from Lake Keowee. This 4,700 sq ft, 4-bedroom, 4-bathroom home is perfect for Clemson football weekends, family gatherings, or lake getaways.Inside, you’ll find room for everyone with multiple living areas, large bedrooms, and four bathrooms. Entertainment is built in with a game room, bar, and private arcade, making the house just as fun to enjoy as the surrounding area. Start your mornings with coffee overlooking the course, and spend your evenings relaxing with family and friends in a private, peaceful setting.Guests love the quiet golf course atmosphere while still being close to everything: Lake Keowee marinas and boat rentals, hiking trails, local dining in downtown Seneca, and Clemson’s stadium.Whether you’re here for game day excitement, a lake adventure, or simply to unwind in a luxury vacation rental, this home combines space, comfort, and location in a way that makes every stay unforgettable.Note:Your safety matters. This property features a Ring doorbell device and flood light that have an exterior security camera facing the front outdoor entry. The camera does not look into any interior spaces. The camera actively records video when motion is detected by the deviceAbout pets:Pets allowed: dogs (limit 2 total).About checkOut:Check out before 11:00 AM.About children:Children allowed: ages 0-17.About checkIn:Check in after 4:00 PM.About smoking:Smoking is not permitted.About minBookingAge:Minimum age to rent: 18.About events:No events allowed.
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Trip.com's insights for hotels in Seneca
Plan smarter with Trip.com’s data-backed insights on travel seasons so that you can book your Seneca hotel at the right time!
What is the cheapest day of the week for hotels in Seneca?
Hotel rates in Seneca are typically lowest on Wednesday, with average nightly rates around PLN 339. Monday tends to be the most expensive, averaging PLN 652 per night.
(Based on Trip.com data from March 17, 2025 to March 17, 2026.)
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PLN 200
PLN 400
PLN 600
PLN 800
PLN 652
Mon
PLN 516
Tue
PLN 339
Wed
PLN 521
Thu
PLN 424
Fri
PLN 608
Sat
PLN 481
Sun
Explore accommodation types in Seneca
Immerse yourself in the vibrant atmosphere of Seneca with our handpicked accommodation options